Levitra and Cialis: PDE - 5 Inhibitors for ED
Guía de Salud Masculina
Levitra (vardenafil) and Cialis (tadalafil) are both medications used to treat erectile dysfunction (ED). Here are some details about them:
1. Mechanism of action
- They belong to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. PDE5 is an enzyme that breaks down cyclic guanosine monophosphate (cGMP) in the penis. By inhibiting PDE5, these medications increase the levels of cGMP, which leads to smooth muscle relaxation in the blood vessels of the penis, allowing increased blood flow and resulting in an erection when sexual stimulation occurs.
2. Onset and duration of action
Levitra:
- The onset of action is relatively fast, typically starting to work within about 30 - 60 minutes after ingestion.
- Its effects can last for about 4 - 5 hours.
Cialis:
- It has a slower onset compared to Levitra, usually taking about 1 - 2 hours to start working.
- However, Cialis is known for its long - lasting effect. The so - called "weekend pill" formulation of Cialis can have effects that last up to 36 hours, allowing for more spontaneity in sexual activity compared to Levitra and Viagra.
Dosage
Levitra:
- The typical starting dose is 10 mg, which can be adjusted up to 20 mg or down to 5 mg depending on the individual's response and tolerability.
Cialis:
- The common starting dose is 10 mg, and it can be increased to 20 mg or decreased to 5 mg as needed. There is also a lower - dose daily formulation (2.5 mg) for those who prefer a more continuous treatment approach.
Side effects
- Both medications can have similar side effects, which may include:
- Headache: This is one of the most common side effects.
- Flushing: A feeling of warmth and redness in the face, neck, or chest.
- Nasal congestion: Stuffy or runny nose.
- Indigestion: Upset stomach, abdominal pain, or nausea.
- Back pain: Some men may experience mild to moderate back pain, more commonly reported with Cialis.
- Vision changes: In rare cases, there may be a temporary alteration in color vision or blurred vision, similar to what can be seen with Viagra (sildenafil), another PDE5 inhibitor.
5. Precautions and contraindications
Medical conditions:
- Men with certain medical conditions such as severe heart disease, low blood pressure, recent stroke or heart attack, or those taking nitrate medications (e.g., nitroglycerin) should not use either Levitra or Cialis. The combination of PDE5 inhibitors and nitrates can cause a dangerous drop in blood pressure.
- They should be used with caution in men with liver or kidney problems, as the dosage may need to be adjusted.
Drug interactions:
- These medications may interact with other drugs, such as alpha - blockers used to treat prostate problems. When used together, they can increase the risk of a significant drop in blood pressure.
It is important that these medications are used under the supervision of a healthcare provider, who can determine the most appropriate treatment option based on an individual's overall health, medical history, and specific needs.
Levitra的主要成分是伐地那非，它通过抑制磷酸二酯酶-5的活性，从而增加一氧化氮的浓度，导致血管扩张，使血液更容易流入阴茎，从而帮助男性实现或维持勃起。
Cialis的主要成分是他达拉非，其作用机制与Levitra相似，也是通过抑制磷酸二酯酶-5来促进血管扩张，增加阴茎血流，帮助男性实现勃起。
两者的主要区别在于它们的药效持续时间和起效速度，Cialis的药效持续时间较长，可以持续36小时左右，而Levitra的药效持续时间相对较短，两者在起效速度上也可能存在差异，具体取决于个体的反应和用药情况。
在选择使用哪种药物时，需要考虑患者的具体情况、医生的建议以及个人偏好，无论使用哪种药物，都需要遵循医生的建议和用药指导，以确保安全有效地使用。
precio Cialis