Tadalafil (20mg): Treating Male Erectile Dysfunction
Guía de Salud Masculina
tadalafil 20 mg is a medication. Here are some key points about it:
1. Pharmacological properties
Mechanism of action
- Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor. PDE5 is an enzyme found in the smooth muscle cells of the blood vessels in the penis (and also in other tissues). By inhibiting PDE5, tadalafil increases the levels of cyclic guanosine monophosphate (cGMP), which leads to smooth muscle relaxation in the penile arteries and subsequent increased blood flow into the penis, facilitating penile erection in response to sexual stimulation.
Pharmacokinetics
Absorption: It is relatively rapidly absorbed, with the maximum plasma concentration typically reached within about 2 hours (although this can vary between individuals). The absorption is not significantly affected by food, so it can be taken with or without food.
Metabolism: Tadalafil is mainly metabolized in the liver by cytochrome P450 enzymes, specifically CYP3A4.
Excretion: It has a long half - life of approximately 17.5 hours, which means it can remain in the body for an extended period. The metabolites are mainly excreted in feces, with a small portion excreted in urine.
Therapeutic uses
Erectile dysfunction (ED)
- Tadalafil 20 mg is commonly prescribed for the treatment of erectile dysfunction in men. It helps improve the ability to achieve and maintain an erection sufficient for sexual intercourse.
Benign prostatic hyperplasia (BPH)
- In some cases, it is also used to treat the symptoms associated with benign prostatic hyperplasia. It can help relieve urinary symptoms such as difficulty in starting urination, weak urinary stream, and frequent urination by relaxing the smooth muscle in the prostate and bladder neck.
3. Precautions and side effects
Precautions
- It should not be used in combination with nitrates (e.g., nitroglycerin) or nitric oxide donors, as this can cause a significant and potentially dangerous drop in blood pressure.
- Patients with certain cardiovascular conditions, such as severe heart failure or recent myocardial infarction, should use tadalafil with caution.
- Those with liver or kidney impairment may require dosage adjustments.
Side effects
- Common side effects may include headache, indigestion, back pain, muscle aches, flushing, and nasal congestion. In rare cases, more serious side effects such as priapism (a prolonged and painful erection lasting more than 4 hours) can occur, which requires immediate medical attention.
他达拉非属于5型磷酸二酯酶抑制剂，通过增加阴茎的血流量来帮助男性获得和维持勃起，这种药物在性刺激的情况下有效，因此需要有性欲或性刺激才能发挥作用。
在使用他达拉非时，请注意以下几点：
1、服用时间：他达拉非可以在性行为前30分钟至4小时服用，效果可持续长达36小时。
2、副作用：常见的副作用包括头痛、消化不良、背痛等，如果出现严重的副作用，如视力变化或听力减退，请立即就医。
3、禁忌症：如果您正在使用硝酸盐类药物（如用于心脏问题的药物），不应使用他达拉非，因为它可能导致危险的血压下降。
4、与其他药物的相互作用：他达拉非可能与某些药物相互作用，因此在开始使用前应告知医生您正在使用的所有药物。
他达拉非是一种有效的治疗勃起功能障碍的药物，但应在医生指导下使用，以确保安全和有效，如果您有任何疑问或不适，建议咨询医生或药师。
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