taladafilo: An Unfamiliar Word in Need of Definition

The question you want to ask may be "tadalafil".

1. Basic information

1、medication type

- Tadalafil is a drug used to treat erectile dysfunction (ED) in men and is a phosphodiesterase type 5 (PDE5) inhibitor.

2、mechanism of action

- During male sexual stimulation, neurons in the corpus cavernosum of the penis release nitric oxide (NO). NO activates guanylate cyclase, increasing cyclic guanosine phosphate (cGMP) levels, causing smooth muscle relaxation and blood flowing into the corpus cavernosum of the penis, causing erection. PDE5 breaks down cGMP. Tadalafil inhibits PDE5 and increases the concentration of cGMP to help maintain erectile function.

2. Clinical application

1、erectile dysfunction treatment

- It can be taken as needed or regularly to improve erectile function. When taking as needed, taking it some time before sexual activity can help patients obtain and maintain erection under sexual stimulation. Taking it regularly (such as taking a small dose every day) also has certain effects on improving patients 'spontaneous erectile function and improving sexual satisfaction.

2、Other potential use studies

- Studies have explored its role in treating pulmonary arterial hypertension. Because PDE5 is also expressed in pulmonary vascular smooth muscle cells, tadalafil can relax pulmonary vessels and reduce pulmonary arterial pressure by inhibiting PDE5.

3. Matters needing attention

1、adverse reactions

- Common adverse reactions include headache, indigestion, back pain, muscle pain, etc. These adverse reactions are usually mild to moderate and generally temporary.

2、contraindications

- Patients who are taking any form of nitrates (such as nitroglycerin) should not use tadalafil because combination of the two may cause severe hypotension and cannot use it in people allergic to tadalafil.