Tadalafil (tadalafil) and Sildenafil (sildenafil) are drugs for the treatment of male erectile dysfunction (ED). There are some differences between them.
Gui í a de Salud Masculina
I. Pharmacological properties
1 、Action time
Tadalafil has a long half-life, about 17.5 hours, which makes it effective for about 36 hours, known as "weekend pills". Patients may respond to sexual stimuli for a long time after taking it. during this time, there is no need to plan the time of sexual life.
Sildenafil
Sildenafil has a relatively short half-life, about 4-5 hours, and its action lasts about 4-6 hours, so sex needs to be closer to medication.
2 、Effective speed
Tadalafil
Tadalafil usually takes effect within 30 minutes to 2 hours after oral administration, but its effect may reach its best relatively slowly in some individuals.
Sildenafil
Sildenafil usually takes effect about 1 hour after oral administration on an empty stomach, and can quickly promote penile erection under sexual stimulation. If taken with food, especially high-fat foods, the onset time may be delayed.
II. Drug safety
1 、Adverse reaction
Tadalafil
Common adverse reactions include headache, indigestion, back pain, muscle pain and so on. Visual abnormalities caused by tadalafil (such as color vision changes, blurred vision, etc.) are relatively rare, but it has also been reported that due to long duration of action, if adverse reactions occur during drug action, they may also last for a long time.
Sildenafil
-adverse reactions such as headache, facial flushing and indigestion may also occur. Visual abnormality is a relatively special adverse reaction of sildenafil. Although the incidence rate is not high, some patients may have temporary blurred vision or blurred vision. Especially in high-dose use, sildenafil has a certain effect on blood pressure and should be used with caution when used with some antihypertensive drugs.
2 、Interact with other drugs
Tadalafil
Tadalafil is metabolized mainly by CYP3A4. When tadalafil is used in combination with CYP3A4 inhibitors (such as ketoconazole, ritonavir, etc.), the blood concentration of tadalafil may increase, increasing the risk of adverse reactions. Tadalafil combined with nitrates is absolutely taboo because it may cause severe hypotension.
Sildenafil
Sildenafil is mainly metabolized by CYP3A4, and its blood concentration will also be increased when combined with CYP3A4 inhibitors. Similarly, sildenafil combined with nitrates can cause severe hypotension, which is taboo. Sildenafil combined with α-receptor blockers may need to adjust the dose to avoid the occurrence of hypotension.
III. Clinical application
1 、intended for
Tadalafil
-for those patients who do not have high sexual frequency but want to maintain sexual flexibility for a longer period of time, for example, some older men with irregular sexual life, the long-term characteristics of tadalafil can reduce the frequency of medication and improve the quality of life.
Sildenafil
-for patients who are more regular in their sexual life and can accurately predict the time of their sexual life, such as younger men whose sexual life is relatively fixed for a certain period of time, sildenafil can be taken at a more appropriate time before the expected sexual life. to achieve a satisfactory erection.
2 、Dosage and usage
Tadalafil
-Tadalafil has a variety of doses to choose from, such as 5mg, 10mg, 20mg and so on. The appropriate dose can be selected according to the patient's specific conditions (such as age, liver and kidney function, drug reaction, etc.). The initial dose is generally recommended as 10mg, and the dose can be adjusted according to the efficacy and tolerance.
Sildenafil
The common doses of sildenafil are 25mg, 50mg and 100mg. Generally, the initial dose is 50mg, which can be adjusted to 25mg or 100mg according to individual reaction. Sildenafil is usually taken as needed about an hour before sexual activity, up to once a day.