Dadalafilo Cialis? Maybe You Mean Dadalafil and Sildenafil for ED.
Guía de Salud Masculina
tadalafil and Cialis are the same drug.
basic information
- Tadalafil is a drug used to treat erectile dysfunction (ED) in men. It can also be used to treat symptoms caused by benign prostatic hyperplasia (BPH) and in some cases to address both ED and BPH related symptoms.
mechanism of action
Affects vascular smooth muscle
- Tadalafil functions mainly by inhibiting the activity of phosphodiesterase 5 (PDE5). Under sexual stimulation, the nerve endings in the corpus cavernosum of the penis release nitric oxide (NO), which activates guanylate cyclase and increases the level of cyclic guanosine phosphate (cGMP), which leads to relaxation of the smooth muscle of the corpus cavernosum and blood flowing into the penis, creating an erection.
- PDE5 degrades cGMP. After tadalafil inhibits PDE5, it can increase the concentration of cGMP and maintain its action time, helping to improve erectile function.
characteristics of drugs
long acting time
- Tadalafil has a long duration of efficacy and is often called a "weekend drug". Its low dose (5mg) can be taken regularly every day. After continuous administration for a period of time, it can stably improve erectile function during sexual stimulation; while the high dose (20mg) when taken as needed can improve erectile function for 36 hours after taking the drug.
precautions
interactions with other medicinal products
- Tadalafil should not be used simultaneously with organic nitrates (such as nitroglycerin, isosorbide mononitrate, etc.) because their combination may cause severe hypotension.
- When coadministered with some antihypertensive drugs (such as alpha-blockers), dose adjustments may be necessary to avoid hypotension.
adverse reactions
- Common adverse reactions include headache, facial flushing, indigestion, nasal congestion, back pain, myalgia, etc. These adverse reactions are usually mild to moderate and gradually disappear after drug metabolism.