What is Tadalafil used for?

tadalafil is primarily used for the following purposes:

1. Treatment of erectile dysfunction (ED)

Mechanism for action:

-Tadalafil inhibits the enzyme phosphodiesterase-5 (PDE-5). This enzyme is responsible for the degradation of nitrogen monoxide (no)-dependent on cyclic guanosine monophosphate (cGMP) in the smooth muscle of the penis. By inhibiting PDE-5, the concentration of cGMP is increased, resulting in smooth muscle relaxation in the penis and allowing normal blood flow to the penis, facilitating erection.

Effectiveness:

-help men with DE to get and maintain an erection suitable for sexual activity.

2. Treatment of pulmonary arterial hypertension (HTPA)

Mechanism for action:

-in HTPA, tadalafil acts at the level of pulmonary blood vessels. By increasing the concentration of cGMP, it results in a relaxation of the smooth muscles of the pulmonary vessels, which decreases pulmonary vascular resistance and, consequently, pulmonary arterial pressure.

Effectiveness:

-it can improve the functional capacity and quality of life of patients with HTPA, relieving symptoms such as dyspnea (shortness of air) and fatigue.

It is important to note that tadalafil should be prescribed by a doctor and consideration should be given to possible side effects and contraindications before use.