Tadalafil 20 mg (Cialis): treating ED by relaxing Penis muscles

tadalafil 20 mg is mainly used to treat erectile dysfunction (ED) in men.

1. Mechanism of action in erectile dysfunction

-Tadalafil acts by inhibiting the enzyme phosphodiesterase-5 (PDE-5). Under normal conditions, during sexual stimulation, the relaxation of smooth muscles in male genital organs is promoted by the release of nitric oxide (no). No activates cyclase guanilate, which increases the concentration of cyclic monophosphate guanosine (cGMP). The cGMP is responsible for relaxing smooth muscles and blood flow to the penis, allowing erection. PDE-5 is responsible for degrading the cGMP. By inhibiting PDE-5, tadalafil allows cGMP to remain at higher levels for longer, facilitating and prolonging erection in response to sexual stimulation.

2. Other potential uses

-its use in erectile dysfunction associated with certain chronic diseases, such as diabetes mellitus, is also being investigated. In addition, in some cases, it has been studied for the treatment of pulmonary hypertension, as it may have beneficial effects on vasodilation of pulmonary blood vessels. However, for these uses it is not indicated exclusively at the 20 mg dose in all cases and requires more specialized medical follow-up.

It is important to note that tadalafil should be prescribed by a doctor and its use must be accompanied by adequate diagnosis and medical advice, as it may have interactions with other medicines and is not suitable for all patients.